comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients
نویسندگان
چکیده
conclusions this study showed that, compared to simply increasing the dose of morphine, adding chloropromazine, promethazine, midazolam, and clinidine to morphine significantly controlled pain scores and increased treatment satisfaction in addicted patients without notable side effects. objectives the objective of this study was to evaluate the analgesic effects of adding clonidine, promethazine, chlorpromazine, and midazolam to morphine in patient-controlled intravenous analgesia (pcia) in orthopedic patients with addiction problems. patients and methods 90 patients with histories of substance abuse were enrolled in this randomized controlled trial. patients were randomly divided into three groups. the first group received 20 mg of morphine sulfate +50 mg of chlorpromazine + 50 mg of promethazine +10 mg of midazolam (m20p). the second group received the first group’s regimen plus 150 micrograms of clonidine (m20pc). the third group received 40 mg of morphine sulfate (m40). a pump with a flow rate of 5 ml/h was chosen. patients were evaluated every 12 hours, and vas, vrs, extra opioid usage, nausea and vomiting, and sedation scores were recorded. results patients’ nausea and vomiting and sedation scores were not statistically different between the three groups. mean vas and vrs scores were found to be statistically lower in the m20pc group than in the other groups. extra opioid usage between the three groups was statistically lower in the m20pc group than in the other groups. the percentage of patients satisfaction was significantly higher in the m20pc group than in the other two groups. background addicted patients present difficulties for pain management because they have another problem besides their pain. adding adjuvants to opioid pumps to intensify quality, control other problems, lengthen analgesia, and reduce side effects has been considered in the field.
منابع مشابه
Comparison of the Efficacy of Adding Clonidine, Chlorpromazine, Promethazine, and Midazolam to Morphine Pumps in Postoperative Pain Control of Addicted Patients
BACKGROUND Addicted patients present difficulties for pain management because they have another problem besides their pain. Adding adjuvants to opioid pumps to intensify quality, control other problems, lengthen analgesia, and reduce side effects has been considered in the field. OBJECTIVES The objective of this study was to evaluate the analgesic effects of adding clonidine, promethazine, ch...
متن کاملefficacy of additives to morphine pumps in post-operative pain control of addicted patients
متن کامل
Efficacy of Additives to Morphine Pumps in Post-Operative Pain Control of Addicted Patients
Acute pain management in opioid dependent patients remains a challenging and complex problem and it is becoming more common (1). In the acute pain setting, in addition to their daily opioid maintenance these patients need a multimodal approach (1). Imani et al. in their study have shown that instead of simply increasing the dosage of morphine, using morphine in addition to chlorpromazine, prome...
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عنوان ژورنال:
anesthesiology and pain medicineجلد ۱، شماره ۱، صفحات ۱۰-۱۴
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